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Primary Research Articles


Juros, D., Avila, M.F., Hastings, R.L., Pendragon, A., Wilson, L., Kay, J., & Valdez, G. (2024) Cellular and moleular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy. Skeletal Muscle

Castro, R.W., Lopes, M.C., De Biase, L.M., & Valdez, G. (2024) Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia


Hastings, R.L., Avila, M.F., Suneby, E., Juros, D., O'Young, A., Peres da Silva, J., & Valdez, G. (2023). Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions. Aging Cell

Castro, R.W., Lopes, M.C., Settlage, R.E., & Valdez, G. (2023). Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans. JCI Insight


Procacci, N.M., Hastings, R.L., Aziz, A.A., Christiansen, N.M., Zhao, J., DeAngeli, C., LeBlanc, N., Notterpek, L., Valdez, G., & Gould, T.M. (2022). Kir4.1 is specifically expressed and active in non-myelinating Schwann cells. Glia

Shapiro, D., Massopust, R., Taetzsch, T., & Valdez, G. (2022). Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1G93A mice. Scientific Reports

Doss, S.V., Barbat-Artigas, S., Lopes, M., Pradhan, B.S., Prószyński, T.J., Robitaille, R., Valdez, G. (2022). Expression and Roles of Lynx1, a Modulator of Cholinergic Transmission, in Skeletal Muscles and Neuromuscular Junctions in Mice. Frontiers in Cell and Developmental Biology

Massopust, R.*, Juros, D.*, Shapiro, D., Lopes, M., Haldar, S.M., Taetzsch, T., & Valdez, G. (2022). KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice. Neurobiology of Disease


Larouche, J.A., Mohiuddin, M., Choi, J.J., Ulintz, P.J., Fraczek, P., Sabin, K., Pitchiaya, S., Kurpiers, S.J., Castor-Macias, J., Liu, W., Hastings, R.L., Brown, L.A., Markworth, J.F., De Silva, K., Levi, B., Merajver, S.D., Valdez, G., Chakkalakal, J.V., Jang, Y.C., Brooks, & Aguilar, C.A. (2021). Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging. eLife

Brayman, V.L, Taetzsch, T., Miko, M., Dahal, S., Risher, C., & Valdez, G. (2021). Roles of the synaptic molecules Hevin and SPARC in mouse neuromuscular junction development and repair. Neuroscience Letters

Taetzsch, T., Shapiro, D., Eldosougi, R., Myers, T., Settlage, R. E., & Valdez, G. (2021). The microRNA miR‐133b functions to slow Duchenne muscular dystrophy pathogenesis. The Journal of Physiology


Castro, R., Taetzsch, T., Vaughan, S. K., Godbe, K., Chappell, J., Settlage, R. E., & Valdez, G. (2020). Specific labeling of synaptic schwann cells reveals unique cellular and molecular features. ELife


Hyer, M.M., Dyer, S.K., Kloster, A., Adrees, A., Taetzsch, T., Feaster, J., Valdez, G., & Neigh, G.N. (2019). Sex modifies the consequences of extended fructose consumption on liver health, motor function, and physiological damage in rats. Am J Physiol Regul Integr Comp Physiol.

Vaughan, S.K., Sutherland, N.M., & Valdez, G. (2019) Attenuating Cholinergic Transmission Increases the Number of Satellite Cells and Preserves Muscle Mass in Old Age. Front Aging Neurosci.

Zeitz, M.J., Calhoun, P.J., James, C.C., Taetzsch, T., George, K.K., Robel, S., Valdez, G., & Smyth, J.W. (2019). Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging. Cell Reports


Herskovits, A.Z., Hunter, T.A., Maxwell, N., Pereira, K., Whittaker, C.A., Valdez, G., & Guarente, L.P. (2018). SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis. Aging Cell

Vaughan, S.K., Sutherland, N.M., Zhang, S., Hatzipetros, T., Vieira, F., & Valdez, G. (2018). The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress. Scientific Reports

Magalhaes-Gomes, M.P.S., Motta-Santos, D., Schetino, L.P.L., Andrade, J.N., Bastos, C.P., Guimaraes, D.A.S., Vaughan, S.K., Martinelli, P.M., Guatimosim, S., Pereira, G.S., Coimbra, C.C., Prado, V.F., Prado, M.A.M., Valdez, G., Guatimosim, C. (2018). Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia. Neurochemistry International

Maxwell, N., Castro, R.W., Sutherland, N.M., Vaughan, K.L., Szarowicz, M.D., de Cabo, R., Mattison, J.A., & Valdez, G. (2018) α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice. Aging Cell

Stockinger, J., Maxwell, N., Shapiro, D., deCabo, R., & Valdez, G. (2018). Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers. The Journals of Gerontology: Series A


Li, P., Fu, X., Smith, N.A.,  Ziobro, J., Curiel, J., Tenga, M., Martin, B., Freedman, S., Cea-Del Rio, C.A., Oboti, L., Tsuchida, T.N., Oluigbo, C., Yaun, A., Magge, S.N., O'Neill, B., Kao, A., Zelleke, T.G., Depositario-Cabacar, D.T., Ghimbovschi, S., Knoblach, S., Ho, C., Corbin, J.G., Goodkin, H.P., Vicini, S., Huntsman, M.M., Gaillard, W.D., Valdez, G., & Liu, J.S. (2017). Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Neuron

Vaughan, S.K., Stanley, O.L., & Valdez, G. (2017). Impact of Aging on Proprioceptive Sensory Neurons and Intrafusal Muscle Fibers in Mice. The Journals of Gerontology: Series A

Taetzsch T, Tenga M, Valdez G. (2017). Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses During Aging and Progression of ALS. Journal of Neuroscience


Sugita, S., Fleming, L.L., Wood, C., Vaughan, S.K., Gomes, M.P.S.M., Camargo, W., Naves, L.A., Prado, V.F., Prado, M.A.M, Guatimosim, C., & Valdez, G. (2016). VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions. Skeletal Muscle

Dalkin, W., Taetzsch, T., & Valdez, G. (2016). The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions. Journal of Visualized Experiments (JoVE)

2015 & Prior

Vaughan, S.K., Kemp, Z., Hatzipetros, T., Vieira, F., & Valdez, G. (2015). Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations. Journal of Comparative Neurology

Dittmar, W.J., McIver, L., Michalak, P., Garner, H.R., & Valdez, G. (2014). EvoCor: a platform for predicting functionally related genes using phylogenetic and expression profiles. Nucleic Acid Research

Valdez, G., Hayer, M.P., Feng, G., & Sanes, J.R. (2014). The role of muscle microRNAs in repairing the neuromuscular junction. PLOS ONE

Samuel, M.A., Valdez, G., Tapia, J.C., Lichtman, J.W., & Sanes, J.R. (2012). Agrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One

Valdez, G., Tapia, J.C., Lichtman, J.W., Fox, M.A., & Sanes, J.R. (2012). Shared resistance to aging and ALS in neuromuscular junctions of specific muscles. PLoS One

Philippidou, P., Valdez, G., Akmentin, W., Bowers, W.J., Federoff, H.J., & Halegoua, S. (2010). Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proceedings of the National Academy of Science

Carlson, S.S., Valdez, G., & Sanes, J.R. (2010). Presynaptic calcium channels and alpha3- integrins are complexed with synaptic cleft laminins, cytoskeletal elements and active zone components. Journal of Neurochemistry

Valdez, G., Tapia, J.C., Kang, H., Clemenson, G.D. Jr, Gage, F.H., Lichtman, J.W., & Sanes, J.R. (2010). Attenuation of age related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci

Williams, A.H.*, Valdez, G.*, Moresi, V., Qi, X., McAnally, J., Elliott, J.L., Bassel-Duby, R., Sanes, J.R., & Olson, E. (2009). MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science

Proszynski, T.J., Gingras, J., Valdez, G., Krzewski, K., & Sanes, J.R. (2009). Podosomes are present in a postsynaptic apparatus and participate in its maturation. Proceedings of the National Academy of Science

Bonanomi, D., Fornasiero, E.F., Valdez, G., Halegoua, S., Benfenati, F., Menegon, A., & Valtorta, F. (2008). Identification of a developmentally-regulated pathway of membrane retrieval in neuronal growth cones. Journal of Cell Science

Nishimune, H., Valdez, G., Miner, J.H., & Sanes, J.R. (2008). Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction. J Cell Biol

Valdez, G., Philippidou, P., Rosenbaum, J., Akmentin, W., Shao, Y., & Halegoua, S. (2007). Trk- signaling endosomes are generated by Rac-dependent macroendocytosis. Proceedings of the National Academy of Science

Valdez, G., Akmentin, W., Kuruvila, R., Ginty, D.D., & Halegoua, S. (2005). Trk macro- endocytosis mediates retrograde axonal signaling. Journal of Neuroscience

Wang, S., Liu, Y., Adamson, C.L., Valdez, G., Guo, W., & Hsu, S.C. (2004). The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization. The Journal of Biological Chemistry

Kuruvilla, R., Zweifel, L.S., Glebova, N.O., Lonze, B.E., Valdez, G., Ye, H., & Ginty, D.D. (2004). A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell

Shao, Y., Akmentin, W., Toledo-Aral, J.J., Rosenbaum, J., Valdez, G., Cabot, J.B., Hilbush, B.S., & Halegoua, S. (2002). Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes. The Journal of Cell Biology

Wurtzel, E.T., Valdez, G., & Matthews, P.D. (1997). Variation in expression of carotenoid genes in transformed E. coli strains. Bioresearch Journal

Wurtzel, E.T., Li, Z., Luo, R., Matias, D., Mozoub, D., Matthews, P.D., Upasani, V.N., Valdez, G., Yoganathan, A., & Yu, J. (1996). Research towards improvement of the pro- vitamin A (carotenoid) content of rice endosperm. International Rice Research Notes

Review Articles

Hastings, R.L. & Valdez, G. (2024) Origin, identity, and function of terminal Schwann cells. Trends in Neuroscience

Valdez, G. (2019) Effects of disease-afflicted and aging neurons on the musculoskeletal system. Bone

Taetzsch, T., Valdez, G. (2018) NMJ maintenance and repair in aging. Curr Opin Physiol.

Taetzsch, T., Brayman, V.L., Valdez, G. (2018) FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system. Biochim Biophys Acta Mol Basis

Book Chapters

Valdez, G. (2020). Chapter 8 - Formation and maturation of neuromuscular junctions (157-184). Patterning and Cell Type Specification in the Developing CNS and PNS