VALDEZ LAB @ BROWN UNIVERSITY

Searching for therapies to fight age-related diseases

AGING, ALS and ALZHEIMER’S DISEASE

Discovering underlying factors that precipitate cellular degeneration

SYNAPSE FORMATION, STABILITY and REPAIR

Searching for molecules with essential functions at synapses

SKELETAL MUSCLES in DISEASES and AGING

Searching for molecules to preserve and repair skeletal muscles

RESEARCH PROJECTS

Learn about our projects on muscle aging, synapse repair, and more

TEAM MEMBERS

Meet our diverse and passionate team of researchers

CONTACT US

Reach out for positions, collaborations, or more information

OUR MISSION

We are interested in identifying molecules that protect synapses from the ravages of aging and age-related neurological diseases. Synapses are the sites where information is received and transmitted throughout the central nervous system and between motor neurons and muscles. They are also a primary site of entry for growth factors and other molecules that neurons and muscles need to properly function and survive. In much of our work, we study the motor neuron and muscle synapse, the neuromuscular junction. This is a large and readily accessible synapse that is significantly affected by normal aging and the progression of diseases, including amyotrophic lateral sclerosis. In parallel, we probe structural and molecular changes in the spinal cord and select brain synapses.