Sydney Vaughan, PhD

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I have been investigating the role of cholinergic transmission in the maintenance of NMJs and skeletal muscles. Using transgenic animal models, I have shown that modulating cholinergic signaling at the NMJ can have negative consequences. Furthermore, I am currently exploring how the protein Lynx1 is involved in regulating cholinergic transmission in skeletal muscles. Lynx1 was previously classified as an endogenous cholinergic modulator through neuronal nicotinic acetylcholine receptors (nAChRs). However, while cholinergic signaling through nAChRs is the main driving force of skeletal muscle contraction, the role of Lynx1 in muscles has largely been overlooked. Using molecular, biochemical, electrophysiological, and imaging techniques I am studying the role of Lynx1 in developing, injured, and disease-affected skeletal muscles and NMJs.