Publications
Vaughan SK, Sutherland NM, Valdez G. (2019) Attenuating Cholinergic Transmission Increases the Number of Satellite Cells and Preserves Muscle Mass in Old Age. Front Aging Neurosci.
Valdez G. (2019) Effects of disease-afflicted and aging neurons on the musculoskeletal system Bone
Taetzsch T, Valdez G. (2018) NMJ maintenance and repair in aging.Curr Opin Physiol.
Vaughan SK, Sutherland NM, Zhang S, Hatzipetros T, Vieira F, Valdez G. (2018) The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress. Sci. Report
Taetzsch T, Brayman VL, Valdez G. (2018) FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system. Biochim Biophys Acta Mol Basis
Maxwell N, Castro RW, Sutherland NM, Vaughan KL, Szarowicz MD, de Cabo R, Mattison JA, Valdez G. (2018) α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice. Aging Cell
Taetzsch T, Tenga M, Valdez G. (2016). Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses During Aging and Progression of ALS. Journal of Neuroscience.
Dalkin W, Taetzsch T, Valdez G. (2016). The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions. Journal of Visualized Experiments (JoVE).
Vaughan SK, Kemp Z, Hatzipetros T, Vieira F, Valdez G. (2015). Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations.Journal of Comparative Neurology 523(17): 2477-94.
Dittmar WJ, McIver L, Michalak P, Garner HR, Valdez G. (2014). EvoCor: a platform for predicting functionally related genes using phylogenetic and expression profiles. Nucleic Acid Research.
Valdez G, Hayer MP, Feng G, Sanes JR. (2014). The role of muscle microRNAs in repairing the neuromuscular junction. PLOS ONE.
Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR. (2012). Agrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One 7(10): e46663.
Valdez G, Tapia JC, Lichtman JW, Fox MA, Sanes JR. (2012). Shared resistance to aging and ALS in neuromuscular junctions of specific muscles. PLoS One 7(4): e34640.
Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. (2010). Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proceedings of the National Academy of Science.
Carlson SS, Valdez G, Sanes JR. (2010). Presynaptic calcium channels and alpha3- integrins are complexed with synaptic cleft laminins, cytoskeletal elements and active zone components.Journal of Neurochemistry.
Valdez G, Tapia JC, Kang H, Clemenson GD Jr, Gage FH, Lichtman JW, Sanes JR. (2010). Attenuation of age related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci USA 107: 14863–68.
Williams AH*, Valdez G*, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson E. (2009). MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 326: 1549–54.
Proszynski TJ, Gingras J, Valdez G, Krzewski K, Sanes JR. (2009). Podosomes are present in a postsynaptic apparatus and participate in its maturation. Proceedings of the National Academy of Science 106: 18373-8.
Bonanomi D, Fornasiero EF, Valdez G, Halegoua S, Benfenati F, Menegon A, Valtorta F. (2008). Identification of a developmentally-regulated pathway of membrane retrieval in neuronal growth cones. Journal of Cell Science 121: 3757-69.
Nishimune H, Valdez G, Miner JH, Sanes JR. (2008). Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction. J Cell Biol 182: 1201-15.
Valdez G, Philippidou P, Rosenbaum J, Akmentin W, Shao Y., Halegoua S. (2007). Trk- signaling endosomes are generated by Rac-dependent macroendocytosis. Proceedings of the National Academy of Science 104: 12270-5.
Valdez G, Akmentin W, Kuruvila R, Ginty DD, Halegoua S. (2005). Trk macro- endocytosis mediates retrograde axonal signaling. Journal of Neuroscience 25: 5236-47.
Wang S, Liu Y, Adamson CL, Valdez G, Guo W, Hsu SC. (2004). The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization. The Journal of Biological Chemistry 279: 35958-66.
Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H, Ginty DD. (2004). A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 118: 243-55.
Shao Y, Akmentin W, Toledo-Aral JJ, Rosenbaum J, Valdez G, Cabot JB, Hilbush BS, Halegoua S. (2002). Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes. The Journal of Cell Biology 157: 679-91.
Wurtzel ET, Valdez G, Matthews PD. (1997). Variation in expression of carotenoid genes in transformed E. coli strains. Bioresearch Journal 1: 1-11.
Wurtzel ET, Li Z-h, Luo R, Matias D, Mozoub D, Matthews PD, Upasani VN, Valdez G, Yoganathan A, Yu J. (1996). Research towards improvement of the pro- vitamin A (carotenoid) content of rice endosperm. International Rice Research Notes 21: 43-44.